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Michael Frink Selected Research

Hemorrhagic Shock

4/2013Induced hypothermia does not impair coagulation system in a swine multiple trauma model.
11/2007Mechanism of salutary effects of finasteride on post-traumatic immune/inflammatory response: upregulation of estradiol synthesis.
4/2007TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage.
3/2007The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage.
1/2005Impact of hypothermia on the immunologic response after trauma and elective surgery.

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Michael Frink Research Topics

Disease

30Wounds and Injuries (Trauma)
08/2021 - 09/2006
17Hemorrhage
11/2011 - 01/2005
12Multiple Trauma (Multiple Injuries)
04/2013 - 01/2005
11Sepsis (Septicemia)
02/2014 - 09/2007
6Inflammation (Inflammations)
02/2012 - 06/2003
5Multiple Organ Failure (MODS)
03/2014 - 02/2007
5Hemorrhagic Shock
04/2013 - 01/2005
4Edema (Dropsy)
08/2008 - 09/2006
3Hypothermia
04/2013 - 01/2005
2Infections
02/2021 - 07/2019
2Thoracic Injuries (Chest Injury)
07/2017 - 04/2013
2Osteoarthritis
07/2016 - 10/2015
2Femoral Neck Fractures
07/2016 - 10/2015
2Abdominal Injuries
10/2015 - 05/2011
2Disease Progression
01/2013 - 05/2011
2Proteinuria
06/2004 - 06/2003
2Fibrosis (Cirrhosis)
06/2004 - 01/2002
2Glomerulonephritis
06/2004 - 06/2003
1Pneumonia (Pneumonitis)
03/2019
1Shoulder Fractures
01/2019
1Arthritis (Polyarthritis)
01/2019
1Ankle Fractures
01/2017
1Open Fractures (Compound Fracture)
01/2017
1Hip Fractures (Intertrochanteric Fractures)
10/2015
1Lacerations
04/2013
1Heart Arrest (Cardiac Arrest)
04/2013
1Overweight
01/2013
1Systemic Inflammatory Response Syndrome (Sepsis Syndrome)
05/2011
1Peritonitis
06/2010
1Heterotopic Ossification (Ectopic Ossification)
10/2009

Drug/Important Bio-Agent (IBA)

11CytokinesIBA
05/2011 - 01/2005
10ChemokinesIBA
08/2011 - 01/2002
9Interleukin-6 (Interleukin 6)IBA
03/2014 - 09/2006
9salicylhydroxamic acid (SHAM)IBA
04/2013 - 03/2007
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2009 - 02/2007
3Interleukin-8 (Interleukin 8)IBA
02/2012 - 02/2007
3Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
08/2011 - 09/2006
3Peroxidase (Myeloperoxidase)IBA
08/2008 - 09/2006
3Estrogens (Estrogen)FDA Link
05/2007 - 04/2007
3Proteins (Proteins, Gene)FDA Link
05/2007 - 01/2002
3Messenger RNA (mRNA)IBA
02/2007 - 01/2002
2Finasteride (Propecia)FDA LinkGeneric
11/2011 - 11/2007
2Toll-Like Receptors (Toll-Like Receptor)IBA
06/2010 - 03/2007
2Interleukin-10 (Interleukin 10)IBA
09/2009 - 02/2007
2Gonadal Steroid Hormones (Sex Hormones)IBA
09/2007 - 02/2007
2SteroidsIBA
09/2007 - 02/2007
2Estradiol (Delestrogen)FDA LinkGeneric
03/2007 - 02/2007
2p38 Mitogen-Activated Protein KinasesIBA
03/2007 - 09/2006
2Chemokine ReceptorsIBA
06/2004 - 01/2002
2CollagenIBA
06/2004 - 01/2002
2BX 471IBA
06/2004 - 01/2002
1Anti-Bacterial Agents (Antibiotics)IBA
02/2021
1Bone Morphogenetic Protein 7IBA
01/2015
1Fibrinogen (Factor I)FDA Link
04/2013
1C-Reactive ProteinIBA
01/2013
1InterleukinsIBA
01/2013
1Chemokine CCL7IBA
08/2011
1AndrostenediolIBA
08/2011
1Blood Alcohol ContentIBA
05/2011
1Ethanol (Ethyl Alcohol)IBA
05/2011
1Hydrogen Sulfide (Sulfide, Hydrogen)IBA
01/2011
1Substance PIBA
01/2011
1LipopolysaccharidesIBA
10/2010
1macrophage stimulatory lipopeptide 2IBA
06/2010
1LipopeptidesIBA
06/2010
1Chemokine CCL3IBA
08/2008
1Hormones (Hormone)IBA
11/2007
1Neutralizing AntibodiesIBA
11/2007
1Chemotactic FactorsIBA
11/2007
1Lactic Acid (Lactate)FDA LinkGeneric
11/2007
1Estrogen Receptor betaIBA
09/2007
1Fatty Acids (Saturated Fatty Acids)IBA
09/2007
1PPAR alphaIBA
09/2007
1peroxisome-proliferator-activated receptor-gamma coactivator-1IBA
09/2007
1Glucose (Dextrose)FDA LinkGeneric
09/2007

Therapy/Procedure

12Resuscitation
10/2015 - 03/2007
5Ligation
11/2011 - 01/2002
4Length of Stay
03/2019 - 02/2007
4Laparotomy
07/2017 - 03/2007
4Therapeutics
10/2016 - 11/2009
4Punctures
11/2011 - 06/2010
3Artificial Respiration (Mechanical Ventilation)
03/2019 - 08/2013
3Induced Hypothermia
04/2013 - 01/2005
3Operative Surgical Procedures
05/2011 - 04/2007
2Reoperation
07/2019 - 01/2017
2Hip Replacement Arthroplasty (Total Hip Replacement)
07/2016 - 10/2015
2Hemiarthroplasty
07/2016 - 10/2015
2Critical Care (Surgical Intensive Care)
06/2013 - 05/2011
1Stents
08/2021
1Arthroplasty
07/2019
1Shoulder Prosthesis
01/2019
1Thoracotomy
07/2017
1Operative Time
01/2017
1Contraindications
10/2015
1Blood Transfusion (Blood Transfusions)
10/2015
1Anesthesia
04/2013
1Heart Transplantation (Grafting, Heart)
04/2013
1Tracheotomy
08/2011
1Immunomodulation
01/2011
1Intramedullary Fracture Fixation
10/2009